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Asymmetric conjugate addition reaction using pyrazole derivatives as a chiral catalyst

✍ Scribed by Choji Kashima; Hiroyo Yokoyama; Saori Shibata; Kiyoshi Fujisawa; Takehiko Nishio

Publisher
Journal of Heterocyclic Chemistry
Year
2003
Tongue
English
Weight
27 KB
Volume
40
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The conjugate addition of Grignard reagent (2) onto 1‐α,β‐unsaturated)acyl 3,5‐dimethylpyrazole (1) was enantioselectively catalyzed by the copper complex from cuprous compounds and 3‐phenyl‐l‐mentho‐pyrazole (3).

📜 SIMILAR VOLUMES

Asymmetric diels alder reaction using py
Asymmetric diels alder reaction using pyrazole derivatives as a chiral catalyst
✍ Choji Kashima; Yohei Miwa; Saori Shibata; Hiroyuki Nakazono 📂 Article 📅 2003 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 79 KB

## Abstract __N__‐Acylpyrazoles (**1**) were promising as good dienophiles, which were easily converted into the desired carboxylic derivatives. Bis(pyrazolyl)methanes, which were derived from chiral pyrazoles, showed the activity of chiral catalyst. Particularly 10 mol% of bis(isomenthopyrazol‐1,1