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Simple and sensitive assay for quantification of oseltamivir and its active metabolite oseltamivir carboxylate in human plasma using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry: Improved applicability to pharmacokinetic study

✍ Scribed by Zhe-Yi Hu; S. Casey Laizure; Bernd Meibohm; Vanessa L. Herring; Robert B. Parker

Book ID
118477750
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
279 KB
Volume
72
Category
Article
ISSN
0731-7085

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## Abstract A rapid, sensitive, and simple ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC/MS/MS) method for the determination of udenafil and its active metabolite, DA‐8164, in human plasma and urine using sildenafil as an internal standard (IS) was developed and validated.