Simple alkyl esters as skin permeation enhancers
β Scribed by David Friend; Paul Catz; Jorge Heller
- Book ID
- 119133769
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 946 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0168-3659
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π SIMILAR VOLUMES
In previous studies (Yoneto et al., 1995. J Pharm Sci 84:312-317; Kim et al., 1992. Int J Pharm 80:17-31; and Warner et al., 2001. J Pharm Sci 90:1143-53), the transport enhancing effects of four homologous series of enhancers-the n-alkanols, 1-alkyl-2-pyrrolidones, 1,2-alkanediols, and N,N-dimethyl
As part of a long-term effort to understand the structure/function relationship between chemical permeation enhancers and skin permeation enhancement, the present study examined the influence of hydrocarbon chain branching on the effectiveness of skin permeation enhancers of the type that possesses
In order to investigate the effect of branching and cyclization in the hydrophobic part of skin permeation enhancers, 17 novel branched-chain and cyclic 6-aminohexanoic acid esters were prepared. Their permeation enhancing activity was evaluated in vitro using human skin and theophylline as a model