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Similarity/dissimilarity studies of protein sequences based on a new 2D graphical representation

✍ Scribed by Yu-Hua Yao; Qi Dai; Ling Li; Xu-Ying Nan; Ping-An He; Yao-Zhou Zhang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
412 KB
Volume
31
Category
Article
ISSN
0192-8651

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✦ Synopsis

Abstract

A (two‐dimensional) 2D graphical representation of protein sequences based on six physicochemical properties of amino acids is outlined. The numerical characterization of protein graphs is given as descriptors of protein sequences. It is not only useful for comparative study of proteins but also for encoding innate information about the structure of proteins. The coefficient of determination is proposed as a new similarity/dissimilarity measure. Finally, a simple example is taken to highlight the behavior of the new similarity/dissimilarity measure on protein sequences taken from the ND6 (NADH dehydrogenase subunit 6) proteins for eight different species. The results demonstrate the approach is convenient, fast, and efficient. Β© 2009 Wiley Periodicals, Inc. J Comput Chem, 2009

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