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Similarities in the thermodynamics and kinetics of aggregation of disease-related Aβ(1–40) peptides

✍ Scribed by Jessica Meinhardt; Gian Gaetano Tartaglia; Amol Pawar; Tony Christopeit; Peter Hortschansky; Volker Schroeckh; Christopher M. Dobson; Michele Vendruscolo; Marcus Fändrich


Book ID
111752935
Publisher
Cold Spring Harbor Laboratory Press
Year
2007
Tongue
English
Weight
404 KB
Volume
16
Category
Article
ISSN
0961-8368

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✍ Wei Qi; Aming Zhang; Dhara Patel; Sungmun Lee; Jamie L. Harrington; Liming Zhao; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB

## Abstract Increasing evidence indicates that soluble aggregates of amyloid beta protein (Aβ) are neurotoxic. However, difficulty in isolating these unstable, dynamic species impedes studies of Aβ and other aggregating peptides and proteins. In this study, hydrogen–deuterium exchange (HX) detected