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Aggregation of the Aβ(1-40) peptide: Secondary structure change from oligomers to fibrils

✍ Scribed by Rabia Sarroukh; Emilie Cerf; Sylvie Derclaye; Yves F. Dufrene; Jean-Marie Ruysschaert; Erik Goormaghtigh; Vincent Raussens


Book ID
118466558
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
6
Category
Article
ISSN
1552-5260

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## Abstract Increasing evidence indicates that soluble aggregates of amyloid beta protein (Aβ) are neurotoxic. However, difficulty in isolating these unstable, dynamic species impedes studies of Aβ and other aggregating peptides and proteins. In this study, hydrogen–deuterium exchange (HX) detected