Silver-catalyzed heterocyclization : First total synthesis of the naturally occurring cis 2-hexadecyl-3-hydroxy-4-methylene butyrolactone

Enantiospecific first total synthesis of

Enantiospecific first total synthesis of (+)-cis,anti,cis-3-hydroxy-1,8,12,12-tetramethyl-4-oxatricyclo[6.4.0.02,6]dodecan-9-yl senecioate, the optical antipode of a natural thapsane isolated from Thapsia villosa

✍ A. Srikrishna; K. Anebouselvy 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 271 KB

The enantiospecific first total synthesis of 10-hydroxy-10,11-epoxythapsan-5-yl senecioate (+)-1f, the enantiomer of the natural thapsane isolated from Thapsia villosa var minor, has been accomplished starting from (R)-carvone.