## Abstract Bone morphogenetic protein‐2 (BMP‐2) plays a key role in osteogenesis. Biomaterials used for the sustained delivery of BMP‐2 __in vivo__ have shown therapeutic benefits. In the present study, BMP‐2 was loaded in porous silk fibroin scaffolds derived from silkworm cocoons (2.4 ± 0.14 μg
✦ LIBER ✦
Silk Fibroin Microparticles as Carriers for Delivery of Human Recombinant Bone Morphogenetic Protein-2: In Vitro and In Vivo Bioactivity
✍ Scribed by Bessa, Paulo César; Balmayor, Elizabeth R.; Hartinger, Joachim; Zanoni, Gerald; Dopler, Daniela; Meinl, Alexandra; Banerjee, Asmita; Casal, Margarida; Redl, Heinz; Reis, Rui L.; van Griensven, Martijn
- Book ID
- 120253062
- Publisher
- Mary Ann Liebert
- Year
- 2010
- Tongue
- English
- Weight
- 926 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1937-3384
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## Abstract The objective of this study was to investigate the efficacy of an injectable calcium phosphate cement/silk fibroin/human recombinant bone morphogenetic protein‐2 composite (CPC/SF/rhBMP‐2) in an ovine interbody fusion model. Twenty‐four mature sheep underwent anterior lumbar interbody f
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