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Silica Nanoparticles as a Highly Efficient Catalyst for the One-Pot Synthesis of 2-Hydroxyacetamide Derivatives from Isocyanides and Electron-Poor Aromatic Aldehydes

✍ Scribed by Ali Ramazani; Amir Mahyari; Hamed Lashgari; Katarzyna Ślepokura; Tadeusz Lis

Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
391 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Reaction of an isocyanide with an electron‐poor aromatic aldehyde in the presence of silica nanoparticles (silica NP; ca. 42 nm) proceeds smoothly at room temperature to afford 2‐hydroxyacetamide derivatives in high yields (Scheme 1 and Table 1).

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