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Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR–ERK activation in renal cell carcinoma

✍ Scribed by Lei Li; Ye Gao; Linlin Zhang; Jin Zeng; Dalin He; Yi Sun

Book ID: 116334905
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 592 KB
Volume: 272
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2008.06.033

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## Abstract Ascochlorin, a non‐toxic prenylphenol compound derived from the fungus __Ascochyta viciae__, has been shown recently to have anti‐cancer effects on various human cancer cells. However, the precise molecular mechanism of this anti‐cancer activity remains to be elucidated. Here, we invest