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Silencing of the HER2/neu Gene by siRNA Inhibits Proliferation and Induces Apoptosis in HER2/neu-Overexpressing Breast Cancer Cells

✍ Scribed by Faltus, Timo; Yuan, Juping; Zimmer, Brigitte; Kramer, Andrea; Loibl, Sibylle; Kaufmann, Manfred; Strebhardt, Klaus

Book ID
122257642
Publisher
Neoplasia Press
Year
2004
Tongue
English
Weight
901 KB
Volume
6
Category
Article
ISSN
1522-8002

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## Abstract Silencing of a specific mRNA using double stranded RNA oligonucleotides represents one of the newest technologies for suppressing a specific gene product. Small interfering RNA (siRNA) are 21 nucleotides long, double stranded RNA fragments that are identical in sequence to the target mR