## Aims: The overexpression of her2/neu receptor plays a key role in tumorigenesis and tumor progression. small molecules targeting her2/neu have therapeutic value in cancers that overexpress her2. in this present study, the effect of houttuyninum, a component in the chinese herbal medicine houttuy
Houttuyninum, an active constituent of Chinese herbal medicine, inhibits phosphorylation of HER2/neu receptor tyrosine kinase and the tumor growth of HER2/neu-overexpressing cancer cells
โ Scribed by Ning-Ning Zhou; Jun Tang; Wen-Dan Chen; Gong-Kan Feng; Bin-Fen Xie; Zong-Chao Liu; Dajun Yang; Xiao-Feng Zhu
- Book ID
- 116720160
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 514 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0024-3205
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## Abstract We have reported that nordihydroguaiaretic acid (NDGA) inhibits the tyrosine kinase activities of the IGFโ1 receptor (IGFโ1R) and the HER2 receptor in breast cancer cells. Herein, we studied the effects of NDGA on the growth of estrogen receptor (ER) positive MCFโ7 cells engineered to o