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Houttuyninum, an active constituent of Chinese herbal medicine, inhibits phosphorylation of HER2/neu receptor tyrosine kinase and the tumor growth of HER2/neu-overexpressing cancer cells

โœ Scribed by Ning-Ning Zhou; Jun Tang; Wen-Dan Chen; Gong-Kan Feng; Bin-Fen Xie; Zong-Chao Liu; Dajun Yang; Xiao-Feng Zhu


Book ID
116720160
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
514 KB
Volume
90
Category
Article
ISSN
0024-3205

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## Abstract We have reported that nordihydroguaiaretic acid (NDGA) inhibits the tyrosine kinase activities of the IGFโ€1 receptor (IGFโ€1R) and the HER2 receptor in breast cancer cells. Herein, we studied the effects of NDGA on the growth of estrogen receptor (ER) positive MCFโ€7 cells engineered to o