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Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells

โœ Scribed by Yuh-Cheng Yang; Yun-Ting Hsu; Chao-Chih Wu; Hsiang-Ting Chen; Mau-Sun Chang


Book ID
116292528
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
585 KB
Volume
343
Category
Article
ISSN
0006-291X

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โœ Jacqueline Brown; Hiromi Higo; Ann Mckalip; Brian Herman ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 128 KB

Infection of cervical epithelial cells with certain high risk HPV genotypes is thought to play an etiologic role in the development of cervical cancer. In particular, HPV type 16 and 18 early protein 6 (E6) is thought to contribute to epithelial transformation by binding to the tumor suppressor prot