✦ LIBER ✦

Significant reduction of brain and CSF amyloid-β in mice following acute administration of a brain-penetrant BACE1 inhibitor

✍ Scribed by Hajos-Korcsok, Eva; Nolan, Charles; Oborski, Christine; Lanyon, Lorraine; Liston, Dane; Ambroise, Claude; Fisher, Katherine; Noell, Stephen; Christoffersen, Curt; Grimwood, Sarah; Hannah, Divine; Bian, Feng; Liu, Jianhua; Nelson, Frederick; Lu, Yasong; Coffey, Heather; Ogilvie, Kevin; Coffman, Karen; Efremov, Ivan; Helal, Christopher; Brodney, Michael; O'Neill, Brian

Book ID: 122431280
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 43 KB
Volume: 6
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2010.05.1816

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

In vivo reduction of beta-amyloid peptid

In vivo reduction of beta-amyloid peptides in the brain of Tg2576 mice after oral administration of a novel BACE1 inhibitor

✍ Susanna Eketjäll; Juliette Jansson; Kristina Eliason; Paulina Appelkvist; Ann-Ca 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 63 KB

Design and Synthesis of β-Site Amyloid P

Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides

✍ Swahn, Britt-Marie; Kolmodin, Karin; Karlström, Sofia; von Berg, Stefan; Söderma 📂 Article 📅 2012 🏛 American Chemical Society 🌐 English ⚖ 620 KB

BACE1 is not the rate-limiting enzyme in

BACE1 is not the rate-limiting enzyme in Aβ production in the brains of APPswe transgenic mice: Pharmacological characterization of BACE1 using novel brain penetrant inhibitors.

✍ Riddell, D.R.; Atchison, K.; Yu, D.; Turner, J.; Wang, E.; Gonzales, C.; Warwick 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 48 KB

O1-04-02: Significant Aβ lowering in CSF

O1-04-02: Significant Aβ lowering in CSF and plasma after oral administration of a potent small molecule BACE1 inhibitor in non-human primates

✍ Adam J. Simon; Marie Holihan; Guoxin Wu; Maria Michener; Diane Posavec; Ming-Tan 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 71 KB

Chronic administration of a novel BACE i

Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8-APPswe/ind mice

✍ Hyde, Lynn A.; Del Vecchio, Robert A.; Kazdoba, Tatiana M.; Manning, Ronald; Ter 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 49 KB

O4-04-08 β-Amyloid reductions in brain,

O4-04-08 β-Amyloid reductions in brain, plasma and CSF of a transgenic mouse model of Alzheimer's disease with a γ-secretase inhibitor

✍ Donna M. Barten; Valerie L. Guss; Jason A. Corsa; Alice T. Loo; Steven B. Hansel 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 161 KB