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Significant effect of acyl groups on enantioselectivity in lipase-catalyzed transesterifications

✍ Scribed by Tadashi Ema; Soichi Maeno; Yusuke Takaya; Takashi Sakai; Masanori Utaka

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
243 KB
Volume
7
Category
Article
ISSN
0957-4166

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✦ Synopsis

The effect of the acyl group of acylating agents on the enantioselectivity in the lipasecatalyzed transesterifications of racemie 2-[(N,N-dimethylearbamoyl)methyl]-3-eyelopenten-l-ol in diisopropyl ether was found 1o be significant. The enantioselectivity was enhanced markedly by changing the aeylating agent from vinyl acetate to vinyl butyrate, and dropped substantially with longer acyl donors. Other acyl donors were also examined.

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