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Enantioselective lipase-catalyzed reactions of methyl pipecolinate: transesterification and N-acylation

✍ Scribed by Arto Liljeblad; Jutta Lindborg; Anu Kanerva; Johanna Katajisto; Liisa T. Kanerva

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 108 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00288-5

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✦ Synopsis

The present research introduces the highly (S)-selective (E>>100) acylation at the secondary ring nitrogen of methyl pipecolinate as a novel resolution method with Candida antarctica lipase A. Catalysis by lipase B leads to reactions at the methyl ester function of the substrate in an almost non-enantioselective manner.

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