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Significant association of acute lymphoblastic leukemia with HLA-Cw7

✍ Scribed by Dr. C.A Müller; R. Hasmann; H. Grosse-Wilde; U. Vögeler; Chen Bei-Jun; R. Dopfer; HD Waller; J.-M. Lalouel

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
477 KB
Volume
5
Category
Article
ISSN
0741-0395

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✦ Synopsis

Frequencies of all defined HLA-A, -B, -C (-DR) antigens were determined in 142 (59) Germans suffering from acute lymphoblastic leukemia (ALL) with differentiation of immunologically defined or age-related subgroups of the disease. A highly significant rise of the HLA-C locus antigen Cw7 was found in ALL patients, particularly those over the age of 11 in comparison with local German and Caucasian controls of the Ninth Int. Histocompatibility Workshop ( W S ) . Only slight differences of HLA-Cw7 frequencies were observed within the four immunologically defined ALL subtypes of all or age-related patient groups. HLA-A, - B, or -DR antigens, as well as HLA-ABC three-locus haplotypes were similarly distributed in patients and their local or Caucasian controls. The results indicate HLA-linked genetic factors conferring susceptibility to ALL in adults, particularly those presenting with B-, T-, and Null-ALL.

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