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โœฆ   LIBER   โœฆ

Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia

โœ Scribed by Susana C. Raimondi; Yinmei Zhou; Susan Mathew; Sheila A. Shurtleff; John T. Sandlund; Gaston K. Rivera; Frederick G. Behm; Ching-Hon Pui

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
140 KB
Volume
98
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

BACKGROUND.

The purpose of the current study was to evaluate the cytogenetic features of the hypodiploid leukemic cells of pediatric patients with this rare subgroup of acute lymphoblastic leukemia (ALL). In addition, the authors determined whether subdivision of the hypodiploid category served a prognostic purpose for these patients.

METHODS.

The authors evaluated the cytogenetic records of 979 patients with ALL admitted to St. Jude Children's Research Hospital (Memphis, TN) between 1984 and 1999.

CONCLUSIONS.

Low hypodiploidy (MN ฯฝ 45) should be recognized as a high-risk feature in pediatric ALL. Only two hypodiploid groups (MN ฯฝ 45 and MN ฯญ 45) may be necessary in prognostic assessments.

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