✦ LIBER ✦

Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia

✍ Scribed by Jing-Yi Shi; Zhi-Hong Ren; Bo Jiao; Run Xiao; Hai-Yang Yun; Bing Chen; Wei-Li Zhao; Qi Zhu; Zhu Chen; Sai-Juan Chen

Publisher: John Wiley and Sons
Year: 2010
Tongue: French
Weight: 217 KB
Volume: 128
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.25318

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Common genetic variations in genes involved in DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment response individually or interactively. However, in acute myeloid leukemia (AML), the relevance of these genetic variations remains to be fully established. In this study, we analyzed 42 genetic variations among 15 candidate genes in 307 AML patients and 560 age‐sex matched controls. Their associations with chemotherapy response were further evaluated in combination with other well‐established prognostic factors. An increased risk of AML was found in individuals heterozygous for XPD 2251A>C (rs13181) with an odds ratio (OR) of 1.637 (95% confidence interval [CI]: 1.118–2.395), and the increased risk could be attributed to C allele (OR = 1.505, 95% CI: 1.061–2.134). Postchemotherapy response analysis revealed that AML patients heterozygous for ATM 4138C>T (rs3092856) or GG homozygous for TP53 215C>G (rs1042522) were independently linked to inferior treatment outcomes. These results uncover novel prognostic factors for AML patients treated with chemotherapy and may also indicate an etiological role of XPD in this disease.

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