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Significance of the CAG repeat length in the androgen receptor gene (AR) for the transactivation function of an M780I mutant AR

✍ Scribed by Ingrid Knoke; Axel Allera; P. Wieacker


Publisher
Springer
Year
1999
Tongue
English
Weight
57 KB
Volume
104
Category
Article
ISSN
0340-6717

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## Abstract Changes in the length of a polymorphic trinucleotide (CAG) repeat in the androgen receptor (AR) gene, which may lead to altered transactivation of the AR gene, have been implicated to play a role in the pathogenesis of several forms of endocrine cancer and certain reproductive disorders

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BACKGROUND. CAG repeat length in exon 1 of the androgen receptor (AR) gene correlates inversely with transcriptional transactivation activity of the AR. Men with shorter AR CAG repeat lengths are at higher risk of prostate cancer. Because benign prostatic hyperplasia (BPH) is an androgen-dependent c