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Significance of Orotate Phosphoribosyltransferase Activity in Renal Cell Carcinoma

✍ Scribed by MIZUTANI, YOICHI; WADA, HIROMI; YOSHIDA, OSAMU; FUKUSHIMA, MASAKAZU; NAKANISHI, HIROYUKI; MIKI, TSUNEHARU

Book ID
122460538
Publisher
Lippincott Williams and Wilkins
Year
2004
Tongue
English
Weight
129 KB
Volume
171
Category
Article
ISSN
0022-5347

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## Abstract ## BACKGROUND 5‐Fluorouracil (5‐FU), an antitumor agent, is used clinically against a variety of malignancies, including bladder carcinoma. 5‐FU is a prodrug, and orotate phosphoribosyltransferase (OPRT) is the principal enzyme that converts 5‐FU directly into an active antitumor metab