Significance of intratumoral genetic heterogeneity in neuroblastomas
β Scribed by Brodeur, Garrett M.
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 43 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0098-1532
- DOI
- 10.1002/mpo.1282
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π SIMILAR VOLUMES
## BACKGROUND. A multiple sampling study was performed on 124 specimens of renal cell carcinomas to analyze the consistency and reliability of DNA measurements. The authors investigated intratumoral DNA heterogeneity and its role as a adverse prognostic factor for disease progression. ## METHODS
Comparative genomic hybridization (CGH) analysis was performed on 36 neuroblastomas of both low and high stage of disease. This study significantly increases the number of neuroblastoma tumors studied by CGH. Analysis of larger series of tumors is particularly important in view of the different clin