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Significance of IgG-subclass antibody determinations in bullous pemphigoid

✍ Scribed by Vijay Kumar; J. E. Valeski; T. P. Chorzeiski; S. Jabionska

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 307 KB
Volume: 10
Category: Article
ISSN: 0887-8013
DOI: 10.1002/(sici)1098-2825(1996)10:6<432::aid-jcla20>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

The presence of circulating basement membrane zone (BMZ) antibodies is characteristic of patients with bullous pemphigoid (BP) and are routinely employed in making the diagnosis. The positive tests, however, occur in 50-70% of patients with BP, thus necessitating consideration of other tests in a significant number of patients. The purpose of this study was to examine the efficacy of indirect immunofluorescence (IF) tests specific for various IgG subclasses antibodies to BMZ in BP, especially in patients who are seronegative on routine indirect IF tests with fluorescein-conjugated

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