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Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia

โœ Scribed by Shinichi Misawa; Shigeo Horiike; Hiroto Kaneko; Yuri Sasai; Yutaka Ueda; Makoto Nakao; Shouhei Yokota; Masafumi Taniwaki; Hiroshi Fujii; Hitoshi Nakagawa; Shouichirou Tsuda; Kei Kashima


Book ID
114119466
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
97 KB
Volume
22
Category
Article
ISSN
0145-2126

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## Abstract Oncogenic mutations in the __KRAS2__, __NRAS__, or __FLT3__ gene are detected in more than 50% of patients with de novo acute myeloid leukemia (AML). __RAS__ mutations are also prevalent in de novo myelodysplastic syndrome (MDS), especially chronic myelomonocytic leukemia and juvenile m