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Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications

✍ Scribed by Christiane Brahimi-Horn; Nathalie Mazure; Jacques Pouysségur


Book ID
113527648
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
528 KB
Volume
17
Category
Article
ISSN
0898-6568

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## ABSTRACT Cigarette smoking is strongly implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mucus hypersecretion is the key manifestation in patients with COPD and mucin 5AC (MUC5AC) is a major component of airway mucus. Hypoxia inducible factor‐1 (HIF‐1) is a transcri