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Hypoxia-inducible factor 1α is upregulated by oncostatin M via Jak/STAT3 and the MEK/Erk1/2 pathway

✍ Scribed by Stefan Vollmer; Valérie Kappler; Jakub Kaczor; Daniela Flügel; Catherine Rolvering; Nobuyuki Kato; Thomas Kietzmann; Iris Behrmann; Claude Haan


Book ID
116398964
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
45 KB
Volume
48
Category
Article
ISSN
1043-4666

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## Abstract ## Objective To examine the roles of STATs 1 and 3 in CCL2 production in human osteoblastic cells and their influences on arthritis development. ## Methods The expression of CCL2 in primary human osteoblasts and U2OS human osteoblastic cells was examined by Northern blotting and enzy