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Signalling: Mixed-lineage kinase control of JNK and p38 MAPK pathways

✍ Scribed by Gallo, Kathleen A.; Johnson, Gary L.

Book ID
109959801
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
859 KB
Volume
3
Category
Article
ISSN
1471-0072

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✦ Synopsis

Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.

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