Proper expression of products of the recombination-activating genes (RAGs) is essential for the development of the adaptive immune system. A major advance in the past year toward understanding RAG regulation is the establishment of green fluorescent protein (GFP)-RAG indicator mouse strains. In vivo
β¦ LIBER β¦
Signaling pathways regulating RAG expression in B lymphocytes
β Scribed by Sophie Hillion; Caroline Rochas; Pierre Youinou; Christophe Jamin
- Book ID
- 113482153
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 346 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1568-9972
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## Abstract Picogram quantities of dinitrophenylated (DNP) dextran, a thymusβindeβpendent antigen or lipopolysaccharide, a B cell mitogen, signal down B lymphocytes to unresponsiveness. Down signals were detected by a decision test in which signaled lymphocytes were allowed one hour to react to an