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Signaling pathways in PACAP regulation of VIP gene expression in human neuroblastoma cells

✍ Scribed by Birgitte Falktoft; Birgitte Georg; Jan Fahrenkrug

Book ID: 113824575
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 898 KB
Volume: 43
Category: Article
ISSN: 0143-4179
DOI: 10.1016/j.npep.2009.08.002

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## Abstract The CD44 adhesion receptor is silenced in highly malignant neuroblastomas (NBs) with __MYCN__ amplification. Because its functional expression is associated with decreased tumorigenic properties, __CD44__ behaves as a tumor suppressor gene in NB and other cancers. Given that the precise