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Signaling pathways in mitochondrial dysfunction and aging

โœ Scribed by Cristina Mammucari; Rosario Rizzuto


Book ID
113776307
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
203 KB
Volume
131
Category
Article
ISSN
0047-6374

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## Abstract Aging of mammalian brain is associated with a continuous decrease of the capacity to produce ATP by oxidative phosphorylation. The impairment of mitochondrial function is mainly due to diminished electron transfer by complexes I and IV, whereas inner membrane H^+^ impermeability and F~1