Signaling antibodies in cancer therapy
β Scribed by Mark S Cragg; Ruth R French; Martin J Glennie
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 93 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
β¦ Synopsis
Abbreviations ADCC antibody-dependent cellular cytotoxicity BCR B cell antigen-receptor CCA cell-cycle arrest EGFR epidermal growth factor receptor FcR Fc receptor Id idiotype IFN-Ξ³ Ξ³ interferon Ξ³ mAb monoclonal antibody MAPK mitogen-activated protein
π SIMILAR VOLUMES
A review of the clinical trials of antibody based cancer therapies reveals that this approach can, in rare cases, induce complete remissions in individual patients with cancer. Since these trials have usually involved patients with large tumor masses, tumor cell inaccessibility is probably a major r
Abbreviations bsAb bispecific antibody
CDR complementarity-determining region C H heavy-chain C-region FACS florescence-activated cell sorters FDA Food and Drug Administration IFOM imaging figure of merit PCR polymerase chain reaction scFv