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Signal Transduction-Mediated Regulation of Urokinase Gene Expression in Human Prostate Cancer

โœ Scribed by Jonathan A. Eandi; Joy C. Yang; Christopher P. Evans

Book ID
115588854
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
180 KB
Volume
288
Category
Article
ISSN
0006-291X

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u-PA contributes to CaP progression, especially in the metastatic androgen-insensitive state. In vitro, u-PA is expressed by androgen-insensitive, but not androgen-sensitive, CaP cell lines. We hypothesized that in androgen-sensitive CaP an activated ARE represses u-PA expression but in androgen-ins