✦ LIBER ✦

Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression

✍ Scribed by Nicola C. Partridge; Sharon R. Bloch; A. Terrece Pearman

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 667 KB
Volume: 55
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240550308

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Identification of signal transduction pa

Identification of signal transduction pathways and promoter sequences that mediate parathyroid hormone 1–38 inhibition of osteoprotegerin gene expression

✍ David L. Halladay; Rebecca R. Miles; Kannan Thirunavukkarasu; Srinivasan Chandra 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 232 KB

## Abstract Osteoprotegerin (OPG), a secreted member of the tumor necrosis receptor superfamily, is a potent inhibitor of osteoclast formation and bone resorption. Parathyroid hormone (PTH), a potent inducer of osteoclast formation, suppresses OPG mRNA expression in vitro and in vivo. To determine

Signal transduction pathways mediating t

Signal transduction pathways mediating the effect of adrenomedullin on osteoblast survival

✍ Sylvie Lausson; Michèle Cressent 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 446 KB

Adrenomedullin (ADM) plays an important role in the regulation of osteoblastic cells through both a proliferative and an anti-apoptotic effects. The present study investigated mechanisms involved in the effect of ADM on survival. We report that ADM can act in osteoblasts both through a non-transcrip

Regulation of parathyroid hormone/parath

Regulation of parathyroid hormone/parathyroid hormone-related protein receptor expression by osteoblast-deposited extracellular matrix in a human osteoblast-like cell line

✍ S. Hausmann; F. M. K. Law; J.-Ph. Bonjour; J. Feyen; R. Rizzoli 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 837 KB

Parathyroid hormone (PTH) receptors and the biological response to PTH in osteoblasts have been shown to be influenced by glucocorticoids, growth factors, cytokines or PTH itself. Furthermore, components of extracellular matrix (ECM) appear to regulate the response to PTH as well. We investigated th

Type I collagen substrate increases calc

Type I collagen substrate increases calcitonin and parathyroid hormone receptor-mediated signal transduction in UMR 106–06 osteoblast-like cells

✍ Kazuto Ikeda; Valdo P. Michelangeli; T. John Martin; David M. Findlay 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 912 KB

Regulation of the osteoblast-specific tr

Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways

✍ Renny T. Franceschi; Guozhi Xiao 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB 👁 1 views

## Abstract The Cbfa1/Runx2 is an important transcription factor necessary for osteoblast differentiation and bone formation. However, the signaling pathways regulating Runx2 activity are just beginning to be understood. Inconsistencies between Runx2 mRNA or protein levels and its transcriptional a

Extracellular-signal regulated kinase si

Extracellular-signal regulated kinase signaling pathway mediates downregulation of type I procollagen gene expression by FGF-2, PDGF-BB, and okadaic acid in osteoblastic cells

✍ Lala R. Chaudhary; Louis V. Avioli 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

Although basic fibroblast growth factor (FGF-2) had been shown to inhibit type I collagen gene expression in osteoblast, its inhibitory mechanism is unknown. In the present study, we investigated the underlying mechanisms by which growth factors downregulate type I collagen gene expression. Treatmen