Side Reactions in Peptide Synthesis: tert-Butylation of Tryptophan
✍ Scribed by Prof. Dr. Erich Wünsch; Dr. Ernst Jaeger; Dr. Lajos Kisfaludy; Dr. Miklos Löw
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 252 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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Syntheses of several Trp-containing peptides on a Wang solid support afforded significant amounts of a side-product. 1 H-NMR and MS data showed that an unexpected alkylation by the linker has occurred on the indole nucleus. This was observed whatever the scavenger used, and whatever the position of