𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A side-reaction in the SPPS of Trp-containing peptides

✍ Scribed by Matthieu Giraud; Florine Cavelier; Jean Martinez

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
86 KB
Volume
5
Category
Article
ISSN
1075-2617

No coin nor oath required. For personal study only.

✦ Synopsis

Syntheses of several Trp-containing peptides on a Wang solid support afforded significant amounts of a side-product. 1 H-NMR and MS data showed that an unexpected alkylation by the linker has occurred on the indole nucleus. This was observed whatever the scavenger used, and whatever the position of the Trp residue in the sequence, unless it was in the C-terminal position.

πŸ“œ SIMILAR VOLUMES

Intermediates and Side-Reactions in the
Intermediates and Side-Reactions in the Synthesis of Molecular Diphenolatonickel Compounds Containing Trimethylphosphane Ligands
✍ Hans-Friedrich Klein; Attila Dal; Thomas Jung; Ulrich FlΓΆrke; Hans-JΓΌrgen Haupt πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 164 KB πŸ‘ 1 views

Admission of molecular oxygen to a solution containing hydroxyphenylnickel compounds Ni(ArЈ) X(PMe 3 ) 3 [ArЈ = 2-OH-C 6 H 4 ; X = Br (6), I (7)], trans-Ni(ArЈ)Cl(PMe 3 ) 2 [ArЈ = 2-Ni(PMe 3 ) 4 and substituted phenols (ArOH) affords bisphenolatonickel compounds trans-Ni(OAr) 2 (PMe 3 ) 2 OH-3,5-Cl

Side Reactions in Organic Synthesis (A G
Side Reactions in Organic Synthesis (A Guide to Successful Synthesis Design) || The Alkylation of Heteroatoms
✍ Zaragoza Dârwald, Florencio πŸ“‚ Article πŸ“… 2005 πŸ› Wiley-VCH Verlag GmbH & Co. KGaA 🌐 German βš– 447 KB πŸ‘ 1 views

Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reac

Side Reactions in Organic Synthesis (A G
Side Reactions in Organic Synthesis (A Guide to Successful Synthesis Design) || The Acylation of Heteroatoms
✍ Zaragoza Dârwald, Florencio πŸ“‚ Article πŸ“… 2005 πŸ› Wiley-VCH Verlag GmbH & Co. KGaA 🌐 German βš– 321 KB πŸ‘ 1 views

Scheme 7.1. Acylations with sterically hindered carboxylic acids [5-8]. Scheme 7.12. Acylation of unprotected amino acids [42, 43]. Scheme 7.13. Regioselective acylation of a 2,6-diaminopurine [44].

Side Reactions in Organic Synthesis (A G
Side Reactions in Organic Synthesis (A Guide to Successful Synthesis Design) || The Stability of Organic Compounds
✍ Zaragoza Dârwald, Florencio πŸ“‚ Article πŸ“… 2005 πŸ› Wiley-VCH Verlag GmbH & Co. KGaA 🌐 German βš– 360 KB πŸ‘ 1 views

Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reac