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Side chain-to-side chain cyclization by click reaction

✍ Scribed by Alexandra Le Chevalier Isaad; Anna Maria Papini; Michael Chorev; Paolo Rovero

Book ID
105359776
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
131 KB
Volume
15
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

Cu^I^‐catalyzed azide‐alkyne 1,3‐dipolar Huisgen's cycloaddition (CuAAC) is a click reaction that has drawn a lot of attention, in general, and in the field of peptide and protein sciences, in particular. Among several reported applications, the preparation of novel heterodetic cyclopeptides by an intramolecular side chain‐to‐side chain CuAAC, forming a 1,4‐disubstituted[1,2,3]triazolyl‐containing bridge, is of great interest. Herein, we provide a detailed protocol for the syntheses of model heterodetic cyclopeptides as a prototypical intramolecular CuAAC, using as a model a sequence derived from parathyroid hormone‐related protein. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.

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