Synthesis of side-chain to side-chain cyclized peptide analogs on solid supports
β Scribed by SCHILLER, PETER W. ;NGUYEN, THI M.-D. ;MILLER, JACK
- Book ID
- 115098289
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 490 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0367-8377
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A novel type of cyclic opioid peptide analogue, cyclo[N epsilon,N epsilon'-carbonyl-D-Lys2,Lys5]enkephalinamide, was prepared from a linear precursor peptide. The peptide was synthesized on the Merrified resin and also by a combination of the solid-phase technique and the classical method in solutio
## Abstract Three analogs of the cytostatic drug ifosfamide incorporating 1βmethylβ2βchloroethyl side chains were designed and prepared as an attempt to obtain drugs of lower toxicity.
## Abstract Six novel cyclic enkephalin analogues have been synthesized. Cyclization of the linear peptides containing basic amino acid residues in position 2 and 5 was achieved by treatment with bis(4βnitrophenyl)carbonate. It was found that some of the compounds exibit unusually high __Β΅__βopioid
## Abstract A new strategy for the synthesis of lipopeptides has been developed. Using Weinreb (__N__βmethoxy, __N__βmethyl) amide as an aldehyde function precursor on the side chains of Asp or Glu residues, this new strategy avoids the synthesis of a lipidic amino acid residue before its incorpora