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Sickle-cell anemia and pulmonary hypertension

✍ Scribed by Glenda M. Ninkovich; Sally K. Miller; Patricia T. Alpert

Book ID: 111359561
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 516 KB
Volume: 22
Category: Article
ISSN: 1041-2972
DOI: 10.1111/j.1745-7599.2010.00493.x

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In patients with sickle cell disease, anemia is a recognized risk factor for stroke, death, and the development of pulmonary hypertension. We have proposed that hemolytic anemia results in endothelial dysfunction and vascular instability and can ultimately lead to a proliferative vasculopathy leadin