Sibyllimycin, 5, 6, 7, 8-Tetrahydro-3-methyl-8-oxo-4-azaindolizidin, ein neuartiger Metabolit aus Thermoactinomyces sp.
✍ Scribed by Doris Hafenbradl; Dr. Martin Keller; Prof. Karl O. Stetter; Priv.-Doz. Dr. Peter Hammann; Frank Hoyer; Dr. Herbert Kogler
- Book ID
- 101531389
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 365 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0044-8249
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Two new natural products, N- (2-methyl-3-oxodec-8-enoyl)corresponding acid chloride, in order to acylate Meldrum's acid. Subsequent aminolysis with pyrrolidine, followed by 2-pyrroline (2) and 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8atetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (3), have been methylation
## Abstract 2‐Propyl‐8‐oxo‐1‐[(2′‐(1H‐tetrazole‐5‐yl) biphenyl‐4‐yl)methyl]‐4, 5, 6, 7‐tetrahydrocyclohept imidazole (KT3‐671), which has been found to be a potent and selective angiotesin II receptor antagonist, was synthesized in ^14^C‐labelled form by using potassium[^14^C]‐cyanide. [^14^C](KT3‐