Sibling-Based Tests of Linkage and Association for Quantitative Traits
โ Scribed by David B. Allison; Moonseong Heo; Norman Kaplan; Eden R. Martin
- Book ID
- 119769987
- Publisher
- American Society of Human Genetics
- Year
- 1999
- Tongue
- English
- Weight
- 129 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/302404
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We develop novel statistical tests for transmission disequilibrium testing (tests of linkage in the presence of association) for quantitative traits using parents and offspring. These joint tests utilize information in both the covariance (or more generally, dependency) between genotype and phenotyp
proposed a regression-based TDT method for quantitative traits consisting of regressing the trait on the parental transmission of a marker allele. Zhu and Elston [2000] also developed a TDT method for quantitative traits by defining a linear transformation to condition out founder information. Both