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Short-, medium- and long-term effects of ursodeoxycholic acid (UDCA) on cholesterol and bile acid synthesis in healthy humans

โœ Scribed by Fischer, S.; Thiessen, K.; Sauter, G.H.; Parhofer, K.; Juengst, D.


Book ID
123444398
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
176 KB
Volume
118
Category
Article
ISSN
0016-5085

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To test whether de nouo synthesis of cholesterol is a limiting factor for bile acid synthesis, we studied the acute effect of simvastatin, an inhibitor of HMGcoenzyme A reductase (the limiting step of cholesterol synthesis) on bile acid synthesis and biliary lipid secretion in subjects with interrup