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Short enantioselective approach to a building block for macrolide syntheses

✍ Scribed by Stürmer, Rainer

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 316 KB
Volume: 1991
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.199119910154

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✦ Synopsis

Abstract

The protected α,β‐dihydroxy aldehyde 2 a key building block for several macrolide antibiotics, has been synthesized from the epoxy alcohol 6. Oxidation furnishes the corresponding aldehyde 7, which is acetalized with ketones in the prescence of SnCl~4~ with complete inversion of configuration at C‐3.

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