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Short Diastereoselective Synthesis of cis- and trans-Hexahydropyrido[2,1-a]isoindole Derivatives.

✍ Scribed by Ala'Eddin Alsarabi; Jean-Louis Canet; Yves Troin

Publisher: John Wiley and Sons
Year: 2005
Weight: 26 KB
Volume: 36
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200511157

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✦ Synopsis

Fused pyridine derivatives R 0450

Short Diastereoselective Synthesis of cis-and trans-Hexahydropyrido[2,1-a]isoindole Derivatives. -Cyclocondensation of 2-formylbenzoic acid (I) with the protected β-amino ketone (II) produces the polycyclic isoindolines (III). The latter can be transformed to a series of derivatives which represent skeletons of natural products and drugs.

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