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Short and straightforward synthesis of 1,7-dimethyl-1,4,7,10-tetraazacyclododecane

✍ Scribed by Giovanni Piersanti; Maria Antonietta Varrese; Vieri Fusi; Luca Giorgi; Giovanni Zappia


Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
245 KB
Volume
51
Category
Article
ISSN
0040-4039

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On the synthesis of 1,4,7-tris(tert-buto
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1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane is widely used as an intermediate in the preparation of medically important DO3A and DOTA metal chelators. Despite its commercial availability and importance, the literature describing the preparation and properties of the free bas