Improved synthesis and application of lanthanide 1,4,7,10-tetrakis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane complexes Ln(DOTP)
✍ Scribed by Dorine W. Swinkels; Godefridus I. Tesser; John P. M. van Duynhoven; Cornelis W. Hilbers
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 521 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0165-0513
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## Abstract The protonation constants of 2‐[4,7,10‐tris(phosphonomethyl)‐1,4,7,10‐tetraazacyclododecan‐1‐yl]acetic acid (H~7~DOA3P) and of the complexes [Ln(DOA3P)]^4−^ (Ln=Ce, Pr, Sm, Eu, and Yb) have been determined by multinuclear NMR spectroscopy in the range pD 2–13.8, without control of ionic
## Abstract Eu^3+^, Dy^3+^, and Yb^3+^ complexes of the dota‐derived tetramide __N__,__N′__,__N″__,__N′′′__‐[1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetrayltetrakis(1‐oxoethane‐2,1‐diyl)]tetrakis[glycine] (H~4~dotagl) are potential CEST contrast agents in MRI. In the [Ln(dotagl)] complexes, the Ln^
## Abstract The lead(II) coordination properties of the tetrapodal ligand DOTAM [1,4,7,10‐tetrakis(carbamoylmethyl)‐1,4,7,10‐tetraaza‐cyclododecane] have been investigated both in the solid state and in solution in order to ascertain the stereoactivity of the lone pair and to rationalize the struct