Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives

✍ Scribed by Vincent Gaumet; Emmanuel Moreau; Abbass Taleb; Fernand Leal; Johan Neyts; Jan Paeshuyse; Claire Lartigue; Olivier Chavignon; Alain Gueiffier; Jean-Claude Teulade; Jacques Métin; Jean-Michel Chezal

• Book ID: 104098339
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 196 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.09.056

✦ Synopsis

2-a]pyrrolo[3,2-c]pyridine Heterocyclization Palladium catalyst Copper catalyst a b s t r a c t Access to N-protected or N-free imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives as potential antiviral compounds was achieved in good yields from N-protected 7-amino-8-halo-2-methylimidazo[1,2-a]pyridines by catalytic coupling of terminal acetylenes under mild conditions using [PdCl 2 (PPh 3 ) 2 ] or [Cu(Phen)(PPh 3 ) 2 ]NO 3 .