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Sheep α-globin gene sequences: Implications for their concerted evolution and for the down-regulation of the 3′ genes

✍ Scribed by Maria S. Ristaldi; Stefania Casula; Andrea Rando; Rita Vestri

Publisher
Springer
Year
1995
Tongue
English
Weight
473 KB
Volume
40
Category
Article
ISSN
0022-2844

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✦ Synopsis

In sheep as in man and most other mammals, there are two a-globin genes (Ia and II(z), which are expressed at different levels, the upstream gene being the most efficient. In a-globin gene triplication and quadruplication, this trend is confirmed, i.e., the cz-chain output of the downstream genes progressively decreases. In this study, we have determined the complete sequence of the cDNAs and of both the introns in a triple-a haplotype in which each gene could be recognized for the presence of distinct alleles. The sequence analysis reveals that the bodies of the three a-globin genes are essentially identical (99.9% homology) and moreover indicates that the down-regulation of additional c~-globin genes in sheep is not the effect of sequence variation from the Cap to the Poly(A) addition sites. This striking similarity among c~-genes is higher than that seen in other mammals and is probably sustained by particularly efficient mechanisms of gene conversion and cross-over fixation.

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