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Sequence and evolution of the gene for the monomeric globin I and its linkage to genes coding for dimeric globins in the insectChironomus thummi

โœ Scribed by Wen-Yen Kao; Thomas Hankeln; Erwin R. Schmidt; Gerald Bergtrom

Publisher
Springer
Year
1995
Tongue
English
Weight
1015 KB
Volume
40
Category
Article
ISSN
0022-2844

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โœฆ Synopsis

We isolated genomic clones containing sequences encoding globins I and IA from a Chironomus thummi thummi genomic library. Three clones contain globin IA (ctt-lA) genes, while one contains a globin I (ctt-1) gene. The coding regions of the four genes are identical except for the single base substitution accounting for the globin I/IA polymorphism. The noncoding DNA flanking the coding region is more than 98% similar, confirming a previous hypothesis that the globin ctt-1 and ctt-lA genes are alleles. Hemoglobins I and IA are monomeric in the insect hemolymph. Earlier in situ hybridization studies suggested that monomeric and dimeric globin genes are clustered at different chromosomal loci. In situ hybridization of ctt-1 DNA to polytene salivary gland chromosomes places the ctt-1 gene on the same band as genes for the dimeric globins II[3 and VIIB, forcing revision of the earlier hypothesis that genes for monomeric and dimeric globin genes are at different loci. The evolution of the ctt-1 and ctt-lA alleles and of the two globin gene loci are discussed.

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