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Shedding of the Matrix Metalloproteinases MMP-2, MMP-9, and MT1-MMP as Membrane Vesicle-Associated Components by Endothelial Cells

✍ Scribed by Giulia Taraboletti; Sandra D'Ascenzo; Patrizia Borsotti; Raffaella Giavazzi; Antonio Pavan; Vincenza Dolo


Book ID
117022431
Publisher
American Society for Investigative Pathology
Year
2002
Tongue
English
Weight
540 KB
Volume
160
Category
Article
ISSN
0002-9440

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## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t