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Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas

✍ Scribed by Forsyth, P A; Wong, H; Laing, T D; Rewcastle, N B; Morris, D G; Muzik, H; Leco, K J; Johnston, R N; Brasher, P M A; Sutherland, G; Edwards, D R

Book ID
110002647
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
417 KB
Volume
79
Category
Article
ISSN
0007-0920

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## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t